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norethisterone acetate
Norethisterone acetate (INN, BAN), also known as norethindrone acetate (USAN), sold under brand names including Aygestin, Gestakadin, Milligynon, Monogest, Norlutate (Canada, USA distributed by ERFA Canada 2012 Inc.〔http://www.eci2012.net/〕), Primolut (Fr., Ger., Swed.), Sovel, Styptin, and others, is a steroidal progestin with additional antigonadotropic (and hence antiandrogen and antiestrogen) effects that is used as a hormonal contraceptive. It is an acetate ester of norethisterone.〔(Norethisterone Acetate @ Drugs.com )〕
Norethindrone acetate is indicated for abnormal uterine bleedings.〔http://www.drugs.com/ppa/norethindrone-acetate.html〕
==Synthesis==
Reaction of norethindrone (1) with acetic anhydride in the presence of ''p''-toluene sulfonic acid, affords norethindrone acetate (2).〔 This in turn affords, on reaction with exess cyclopentanol in the presence of excess phosphorus pentoxide, the 3-cyclopentyl enol ether (3),〔 the progestational component of Riglovic®.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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